The PICASO platform is an innovative cloud solution that facilitates interoperability across distributed data sources. It enables care organisations to benefit from cloud technologies and experience benefits of scalability and software resource sharing without violating regulations regarding clinical data. The cloud is divided into three loosely coupled node types. All software for care management and decision support is hosted in one public cloud while all clinical data resides inside the care organisations. All access and use of clinical data are done in a secure and authorised way in accordance with the General Data Protection Regulation (GDPR).